Association of nonsynonymous substitutions in the intermediate region of the vacA gene of Helicobacter pylori with gastric diseases in Taiwan.
نویسندگان
چکیده
The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGITSSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the i1-type cluster C sequence could be a marker of VacA in the Taiwanese strains.
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 47 1 شماره
صفحات -
تاریخ انتشار 2009